Anti-BCA2/ZNF364/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-BCA2/ZNF364/FITC Conjugated抗体

Anti-BCA2/ZNF364/FITC Conjugated抗体

商家询价

产品名称： Anti-BCA2/ZNF364/FITC Conjugated抗体

英文名称： Anti-BCA2/ZNF364/FITC

产品编号： YB--6757R-FITC

产品价格： null

产品产地： 中国/美国

品牌商标： Ybscience

更新时间： 2023-08-17T10:29:50

使用范围： 科研使用

上海钰博生物科技有限公司
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 Anti-BCA2/ZNF364/FITC Conjugated抗体

产品编号 YB-6757R-FITC
英文名称 Anti-BCA2/ZNF364/FITC
中文名称 FITC标记的乳腺癌相关基因2抗体（锌指蛋白364）
别    名 BCA2; Breast cancer associated gene 2; CL469780; Rabring 7; RING finger protein 115; RNF115; Zinc finger protein 364; ZNF364; ZNF 364; RN115_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  细胞类型标志物  肿瘤细胞生物标志物  锌指蛋白  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 34kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF364/BCA2/RNF115
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.

Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.

Subunit:
Interacts with RAB7A. 

Subcellular Location:
Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity).

Tissue Specificity:
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.

Post-translational modifications:
RING-type zinc finger-dependent and E2-dependent autoubiquitination. 

Similarity:
Contains 1 RING-type zinc finger. 

Database links:

Entrez Gene: 101060478 Human

Entrez Gene: 27246 Human

Entrez Gene: 67845 Mouse

Entrez Gene: 362002 Rat

SwissProt: Q9Y4L5 Human

SwissProt: Q9D0C1 Mouse

Unigene: 523550 Human

Unigene: 386792 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.