Anti-TIMP-1/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-TIMP-1/FITC Conjugated抗体
英文名称: Anti-TIMP-1/FITC
抗体货号: YB--4600R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human TIMP-1
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/17 9:27:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-TIMP-1/FITC Conjugated抗体

产品编号 YB-4600R-FITC
英文名称 Anti-TIMP-1/FITC
中文名称 FITC标记的金属蛋白酶组织抑制因子-1抗体
别    名 Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  细胞凋亡  生长因子和***  激酶和***酸酶  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMP-1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].

Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP1 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

Database links:

Entrez Gene: 7076 Human

Entrez Gene: 21857 Mouse

Omim: 305370 Human

SwissProt: P01033 Human

SwissProt: P12032 Mouse

Unigene: 522632 Human

Unigene: 8245 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

TIMP1是基质金属蛋白酶的抑制酶,其功能与MMP相反,能抑制肿瘤细胞的浸润和转移,主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-1是一种28kDa的糖蛋白,主要分泌细胞为多种结缔组织细胞,被认为是组织中MMPs活性的主要调节者,它可以和MMPs家族成员以共价键方式形成1:1的复合物,从而发挥其抑制作用。在正常生理条件下,MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的,一旦它们之间的比例失调,就会造成一系列的病理状态

 

 

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