Anti-SCN11A/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-SCN11A/FITC Conjugated抗体
英文名称: Anti-SCN11A/FITC
抗体货号: YB--6684R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human SCN11A/NAV1.9 (656-705aa)
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/4/17 9:49:00
详细资料:  实验方法技术资料
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诚信指数:1658点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-SCN11A/FITC Conjugated抗体

产品编号 YB-6684R-FITC
英文名称 Anti-SCN11A/FITC
中文名称 FITC标记的钠通道蛋白11α抗体
别    名 hNaN; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN 5; PN5; SCN 11A; SCN 12A; SCN12A; Sensory neuron sodium channel 2; SNS 2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; Sodium channel voltage gated type XI alpha; Sodium channel voltage gated type XI alpha polypeptide; Sodium channel voltage gated type XI alpha subunit; Sodium channel voltage gated type XII alpha polypeptide; Voltage gated sodium channel Nav1.9; Voltage gated sodium channel subunit alpha Nav1.9; SCNBA_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  通道蛋白  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 197kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCN11A/NAV1.9 (656-705aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Voltage gated sodium channels are membrane protein complexes that play a fundamental role in generating and transmitting action potentials in neuronal cells. SCN11A (Sodium channel, voltage gated, type XI, alpha subunit) mediates the voltage dependent sodium ion permeability and conductance. It forms the pore of the sodium selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin resistant sodium channel isoform.

Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.

Subunit:
he voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.

Similarity:
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.

Database links:

Entrez Gene: 11280 Human

Entrez Gene: 29701 Rat

Omim: 604385 Human

SwissProt: Q9UI33 Human

SwissProt: O88457 Rat

Unigene: 591657 Human

Unigene: 30023 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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