Anti-MSH gamma/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-MSH gamma/FITC Conjugated抗体

Anti-MSH gamma/FITC Conjugated抗体

商家询价

产品名称: Anti-MSH gamma/FITC Conjugated抗体

英文名称: Anti-MSH gamma/FITC

产品编号: YB--3918R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-MSH gamma/FITC Conjugated抗体

产品编号 YB-3918R-FITC
英文名称 Anti-MSH gamma/FITC
中文名称 FITC标记的促黑细胞激素γ抗体
别    名 Gamma MSH; Melanocyte Stimulating Hormone; Melanotropin gamma; POMC; Proopiomelanocortin; COLI_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 1.5/29kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MSH gamma (YVMGHFRWDRF)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function:
ACTH stimulates the adrenal glands to release cortisol. 
MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. 
Beta-endorphin and Met-enkephalin are endogenous opiates. 

Subcellular Location:
Secreted.

Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.

Post-translational modifications:
pecific enzymatic cleavages at paired basic residues yield the different active peptides. 
O-glycosylated; reducing sugar is probably N-acetylgalactosamine. 

DISEASE:
Defects in POMC may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. 
Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair. 

Similarity:
Belongs to the POMC family.

Database links:

Entrez Gene: 5443 Human

Entrez Gene: 18976 Mouse

Entrez Gene: 24664 Rat

Omim: 176830 Human

SwissProt: P01190 Cow

SwissProt: P01189 Human

SwissProt: P01193 Mouse

SwissProt: P01194 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.