Anti-IL12RB2/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-IL12RB2/FITC Conjugated抗体

Anti-IL12RB2/FITC Conjugated抗体

商家询价

产品名称: Anti-IL12RB2/FITC Conjugated抗体

英文名称: Anti-IL12RB2/FITC

产品编号: YB--2604R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-IL12RB2/FITC Conjugated抗体

产品编号 YB-2604R-FITC
英文名称 Anti-IL12RB2/FITC
中文名称 FITC标记的白细胞介素-12受体β2抗体
别    名 Interleukin-12 receptor subunit beta-2; RP11-102M16.1; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-12RB2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq].

Function:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

Subcellular Location:
Membrane; Single pass type I membrane protein. 

Tissue Specificity:
Isoform 2 is expressed at similar levels in both naive and activated T-cells.

Post-translational modifications:
On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.

Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.

Database links:

Entrez Gene: 282452 Cow

Entrez Gene: 489550 Dog

Entrez Gene: 100722774 Guinea pig

Entrez Gene: 3595 Human

Entrez Gene: 16162 Mouse

Entrez Gene: 397178 Pig

Entrez Gene: 100350416 Rabbit

Entrez Gene: 171334 Rat

Entrez Gene: 100820736 Sheep

Omim: 601642 Human

SwissProt: Q99665 Human

SwissProt: P97378 Mouse

Unigene: 479347 Human

Unigene: 188337 Mouse

Unigene: 207395 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications