Anti-Angiopoietin 2/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Angiopoietin 2/FITC Conjugated抗体

Anti-Angiopoietin 2/FITC Conjugated抗体

商家询价

产品名称: Anti-Angiopoietin 2/FITC Conjugated抗体

英文名称: Anti-Angiopoietin 2/FITC

产品编号: YB--0677R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-Angiopoietin 2/FITC Conjugated抗体

产品编号 YB-0677R-FITC
英文名称 Anti-Angiopoietin 2/FITC
中文名称 FITC标记的血管生成素2抗体
别    名 AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand; ANGP2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  生长因子和激素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Angiopoietin 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Subunit:
Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.

Subcellular Location:
Secreted.

Similarity:
Contains 1 fibrinogen C-terminal domain.

Database links:

Entrez Gene: 285 Human

Entrez Gene: 11601 Mouse

Entrez Gene: 89805 Rat

Omim: 601922 Human

SwissProt: O15123 Human

SwissProt: O35608 Mouse

SwissProt: O35462 Rat

Unigene: 583870 Human

Unigene: 439874 Mouse

Unigene: 138360 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

血管生成素2(angiopoietin-2, Ang-2)是Ang家族的成员之一,是特异性血管生成刺激因子,也是恶性肿瘤早期的标志分子.