Anti-AHR/FITC Conjugated抗体
产品名称： Anti-AHR/FITC Conjugated抗体
英文名称： Anti-AHR/FITC
产品编号： YB--1416R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
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- 邮编 : 200612
- 所在区域 : 上海
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- 邮箱 : shybio@126.com
Anti-AHR/FITC Conjugated抗体
| 产品编号 | YB-1416R-FITC |
| 英文名称 | Anti-AHR/FITC |
| 中文名称 | FITC标记的芳香烃受体抗体 |
| 别 名 | Ah receptor; AHR; Aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; Aryl hydrocarbon receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 93kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Aryl Hydrocarbon Receptor |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. Function: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Subcellular Location: Cytoplasm. Nucleus. Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. Tissue Specificity: Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. Database links: Entrez Gene: 196 Human Entrez Gene: 11622 Mouse Entrez Gene: 25690 Rat Omim: 600253 Human SwissProt: P35869 Human SwissProt: P30561 Mouse SwissProt: P41738 Rat Unigene: 171189 Human Unigene: 341377 Mouse Unigene: 91370 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） 芳香烃受体（AHR）是一种配体激活转录因子,可介导多环芳烃类化合物的毒性（包括致癌性）反应,还参与一些重要的生物学过程,如信号转导、细胞分化、细胞凋亡等。人体的肺、肝、肾、胎盘、腭扁桃体、B淋巴细胞等各种组织和细胞中都存在AHR。AHR对生长发育和生理功能等具有调控作用,在一些癌症（乳腺癌和卵巢癌等）发生发展中起促进作用 |