Anti-Bak/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Bak/FITC Conjugated抗体

Anti-Bak/FITC Conjugated抗体

商家询价

产品名称: Anti-Bak/FITC Conjugated抗体

英文名称: Anti-Bak/FITC

产品编号: YB--1284R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 邮箱 : shybio@126.com

 Anti-Bak/FITC Conjugated抗体

产品编号 YB-1284R-FITC
英文名称 Anti-Bak/FITC
中文名称 FITC标记的Bcl-2同源拮抗剂抗体
别    名 Apoptosis Regulator Bak; BAK 1; BAK; BAK like; Bak NT; BAK1; Bcl 2 homologous antagonist/killer; Bcl 2 like 7 protein; Bcl2 homologous antagonist killer; Bcl2 like 7 Protein; BCL2-antagonist/killer 1; BCL2L7; CDN 1; CDN1; Cell death inhibitor 1; MGC117255; MGC3887; NBak; Pro apoptotic protein BAK; BAX_MOUSE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 23kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Bak
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

Function:
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.

Subunit:
Belongs to the Bcl-2 family.

Subcellular Location:
Mitochondrion membrane.

Tissue Specificity:
Expressed in a wide variety of tissues.

Similarity:
Belongs to the Bcl-2 family.

Database links:


Entrez Gene: 578 Human

Entrez Gene: 12018 Mouse

Omim: 600516 Human

SwissProt: Q16611 Human

SwissProt: Q6I9T6 Human

SwissProt: O08734 Mouse

Unigene: 485139 Human

Unigene: 2443 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Bak属于bcl-2基因家族中的成员,具有抑制凋亡的作用。BAK基因是新发现的细胞凋亡促进因子,BAK含BH1和BH2结构域,其功能类似于BAX;拮抗BCL2、BCL-XL的抗凋亡效应