Anti-ARIP2B/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-ARIP2B/FITC Conjugated抗体
英文名称: Anti-ARIP2B/FITC
抗体货号: YB--0801R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from hamn ARIP2B
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Mouse, Rat, Cow,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/5/15 10:48:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-ARIP2B/FITC Conjugated抗体

产品编号 YB-0801R-FITC
英文名称 Anti-ARIP2B/FITC
中文名称 FITC标记的激活素受体2B抗体
别    名 Activin A receptor type IIB; Activin receptor type 2B; ActR IIB; ACTR-IIB; ActRIIB; ACVR 2B; ACVR2B; MGC116908; AVR2B_HUMAN; Activin receptor type IIB; Activin receptor type-2B; HTX4;MGC116908.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, Cow, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 56kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from hamn ARIP2B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Activin receptor type-2B( Activin receptor type IIB; ACTR-IIB ) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. [Subcellular Location] Membrane; Single-pass type I membrane protein. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Function:
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Subunit:
Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. 

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity. 

DISEASE:
Heterotaxy, visceral, 4, autosomal (HTX4) [MIM:613751]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 protein kinase domain. 

Database links:

Entrez Gene: 374213 Chicken

Entrez Gene: 282131 Cow

Entrez Gene: 93 Human

Entrez Gene: 11481 Mouse

Entrez Gene: 448845 Pig

Entrez Gene: 25366 Rat

Omim: 602730 Human

SwissProt: Q90670 Chicken

SwissProt: Q95126 Cow

SwissProt: Q13705 Human

SwissProt: P27040 Mouse

SwissProt: Q66T47 Pig

SwissProt: P38445 Rat

Unigene: 174273 Human

Unigene: 390239 Mouse

Unigene: 24240 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 


ARIP2b属于ARIP家族新成员,在脑组织、垂体、睾丸中表达较高,胰腺、卵巢组织中有表达

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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