Anti-TLR5/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-TLR5/FITC Conjugated抗体
英文名称: Anti-TLR5/FITC
抗体货号: YB--1197R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from mouse TLR5
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/5/15 10:49:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-TLR5/FITC Conjugated抗体

产品编号 YB-1197R-FITC
英文名称 Anti-TLR5/FITC
中文名称 FITC标记的Toll样受体5抗体
别    名 toll-like receptor 5; FLJ10052; MGC126430; MGC126431; TIL 3; TIL3; TLR 5; Toll like receptor 5; Toll like receptor 5 precursor; Toll/interleukin 1 receptor like protein 3;CD285; TLR5_MOUSE.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  细胞膜受体  细菌及病毒  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 95kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse TLR5
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens. 

Function:
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Subunit:
Homodimer both in the absence and presence of ligand. Binds MYD88 via their respective TIR domains (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein (By similarity).

Tissue Specificity:
Highly expressed in liver. Detected in lung and at very low levels in most other tissues.

Post-translational modifications:
Phosphorylated at Tyr-799 upon flagellin binding; required for signaling (By similarity).

Similarity:
Belongs to the Toll-like receptor family. 
Contains 16 LRR (leucine-rich) repeats. 
Contains 1 TIR domain.

Database links:

Entrez Gene: 7100 Human

Entrez Gene: 53791 Mouse

Omim: 603031 Human

SwissProt: O60602 Human

SwissProt: Q9JLF7 Mouse

Unigene: 604542 Human

Unigene: 116894 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Toll样受体5可在单核细胞、未成熟树突状细胞及上皮细胞表达 ,可能是一种参与免疫应答的受体 ,其具体作用尚不清楚。
TLR5可辨认鞭毛蛋白(fla-gellin),此种蛋白可组成鞭毛,与细菌泳动有关

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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