Anti-ETS1/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-ETS1/FITC Conjugated抗体
英文名称: Anti-ETS1/FITC
抗体货号: YB--1285R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human Ets1
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/5/15 10:50:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-ETS1/FITC Conjugated抗体

产品编号 YB-1285R-FITC
英文名称 Anti-ETS1/FITC
中文名称 FITC标记的转录因子家族ETS1抗体
别    名 Avian erythroblastosis virus E26 (v ets) oncogene homolog 1; C ets 1 protein; ETS 1; Ets protein; ETS-1; ETS1 protein; ETS1_HUMAN; EWSR 2; EWSR2; FLJ10768; p54; Protein C-ets-1; v ets avian erythroblastosis virus E2 oncogene homolog; v ets avian erythroblastosis virus E26 oncogene homolog 1; v ets erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, G
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Ets1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Function:
Transcription factor.

Subunit:
Interacts with MAF and MAFB. Interacts with PAX5, the interaction alters DNA-binding properties. Binds to DAXX. Interacts with UBE2I.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.
Ubiquitinated; which induces proteasomal degradation.

Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.

Database links:

Entrez Gene: 540313 Cow

Entrez Gene: 2113 Human

Entrez Gene: 23871 Mouse

Entrez Gene: 24356 Rat

Omim: 164720 Human

SwissProt: P13474 Chicken

SwissProt: P15062 Chicken

SwissProt: P14921 Human

SwissProt: P27577 Mouse

SwissProt: P41156 Rat

Unigene: 369438 Human

Unigene: 292415 Mouse

Unigene: 88756 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Ets家族成员在胚胎发生早期的血细胞生成和血管发生及胚胎发育后期的组织发生中发挥重要的调控作用. 成年后Ets在许多组织,如造血组织、血管、脑和中枢神经系统、乳腺、子宫内膜、卵巢、睾丸、肾和肺中均有表达. 由于Ets转录因子不同成员在胚胎发育过程中的特异性的表达与其功能关系密切。
Ets家族的重要成员Ets-1的表达与胰腺癌、甲状腺癌、乳腺癌、胃癌、子宫内膜癌、口腔鳞癌、肝细胞性肝癌(HCC)的发生、转移有很重要的关系

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