Anti-DEK/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-DEK/FITC Conjugated抗体
英文名称: Anti-DEK/FITC
抗体货号: YB--0874R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human DEK
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Chicken, Dog, Cow,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/6/11 14:03:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-DEK/FITC Conjugated抗体

产品编号 YB-0874R-FITC
英文名称 Anti-DEK/FITC
中文名称 FITC标记的DEK癌基因结合蛋白
别    名 D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DNA binding; DEK_HUMAN; OTTHUMP00000039357; Protein DEK.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 染色质和核信号  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DEK
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The DEK gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA which then induces positive supercoils into closed circular DNA, and is also involved during mRNA processing in splice site selection. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.

Function:
Involved in chromatin organization.

Subunit:
Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with histones H2A, H2B, H3, H4, acetylated histone H4, non-phosphorylated DAXX and HDAC2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Binds DNA.

Subcellular Location:
Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei. 

Tissue Specificity:
Ubiquitous. Expressed at relatively high levels.

Post-translational modifications:
Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA.

DISEASE:
Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.

Similarity:
Contains 1 SAP domain.

Database links:

Entrez Gene: 7913 Human

Entrez Gene: 110052 Mouse

Entrez Gene: 306817 Rat

Omim: 125264 Human

SwissProt: P35659 Human

SwissProt: Q7TNV0 Mouse

SwissProt: Q6AXS3 Rat

Unigene: 484813 Human

Unigene: 131150 Mouse

Unigene: 25099 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

DEK癌基因结合蛋白,主要参与DNA核转录。目前多用于白血病及急性髓系白血病的研究

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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