Anti-TOP1MT/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-TOP1MT/FITC Conjugated抗体
英文名称: Anti-TOP1MT/FITC
抗体货号: YB--1211R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human TOP1mt
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/6/27 12:22:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-TOP1MT/FITC Conjugated抗体

产品编号 YB-1211R-FITC
英文名称 Anti-TOP1MT/FITC
中文名称 FITC标记的线粒体DNA拓普西异构酶Ⅰ抗体
别    名 Topoisomerase (DNA) I, mitochondrial; mitochondrial DNA topoisomerase I; DNA topoisomerase I, mitochondrial; TOP1mt; 2900052H09Rik; TOP1MT; TOP1M_HUMAN; DNA topoisomerase I, mitochondrial; mitochondrial; TOP1mt; Topoisomerase I mitochondrial.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  染色质和核信号  转录调节因子  激酶和***酸酶  线粒体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TOP1mt
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Function:
Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

Subcellular Location:
Mitochondrion.

Tissue Specificity:
Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.

Similarity:
Belongs to the type IB topoisomerase family.

Database links:

Entrez Gene: 116447 Human

Omim: 606387 Human

SwissProt: Q969P6 Human

Unigene: 528574 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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