Anti-STAT6/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-STAT6/FITC Conjugated抗体
英文名称: Anti-STAT6/FITC
抗体货号: YB--1143R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human STAT6
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/4 14:16:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海钰博生物科技有限公司
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产品详细描述

 Anti-STAT6/FITC Conjugated抗体

产品编号 YB-1143R-FITC
英文名称 Anti-STAT6/FITC
中文名称 FITC标记的信号转导和转录激活因子6抗体
别    名 signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  发育生物学  信号转导  细胞凋亡  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human STAT6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.

Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Post-translational modifications:
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 6778 Human

Entrez Gene: 20852 Mouse

Entrez Gene: 362896 Rat

Omim: 601512 Human

SwissProt: P42226 Human

SwissProt: P52633 Mouse

Unigene: 524518 Human

Unigene: 121721 Mouse

Unigene: 6880 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

信息转导和转录激活因子-6(signal transducer and activator of transcription-6,STAT6)是信号转导和转录激活因子(STAT)家族的一员,是一种94kD的蛋白质。它通过JAK-STAT信号转导途径介导细胞因子IL-3、IL-4及IL-13诱导的基因表达,特别是在促进IL-4诱导的MHCⅡ类抗原及免疫球蛋白受体等的表达及Th2细胞和淋巴细胞的

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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