Anti-TIMP-2/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-TIMP-2/FITC Conjugated抗体
英文名称: Anti-TIMP-2/FITC
抗体货号: YB--0416R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human TIMP-2 (125-160aa)
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/6/6 12:03:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-TIMP-2/FITC Conjugated抗体

产品编号 YB-0416R-FITC
英文名称 Anti-TIMP-2/FITC
中文名称 FITC标记的金属蛋白酶组织抑制因子-2抗体
别    名 Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  神经生物学  信号转导  细胞凋亡  生长因子和***  合成与降解  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 24kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TIMP-2 (125-160aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subunit:
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

Subcellular Location:
Secreted.

Post-translational modifications:
The activity of TIMP2 is dependent on the presence of disulfide bonds.

Similarity:
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain.

Database links:

Entrez Gene: 282093 Cow

Entrez Gene: 100135629 Guinea pig

Entrez Gene: 7077 Human

Entrez Gene: 21858 Mouse

Entrez Gene: 100008689 Rabbit

Entrez Gene: 29543 Rat

Omim: 188825 Human

SwissProt: P16368 Cow

SwissProt: Q9WUC6 Guinea pig

SwissProt: P16035 Human

SwissProt: P25785 Mouse

SwissProt: Q9TRZ7 Rabbit

SwissProt: P30121 Rat

Unigene: 633514 Human

Unigene: 206505 Mouse

Unigene: 10161 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

合成与降解(Synthesis and Degradation)
TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶,其功能与MMP相反,能抑制肿瘤细胞的浸润和转移,主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-2又称为CSC-21K,是一种21-24kDa的糖蛋白,在多种组织细胞中表达,它可以和MMPs家族成员以共价键方式形成复合物,从而发挥其抑制作用。在正常生理条件下,MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的,一旦它们之间的比例失调,就会造成一系列的病理状态

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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