Anti-SHANK 1/FITC Conjugated抗体
产品名称： Anti-SHANK 1/FITC Conjugated抗体
英文名称： Anti-SHANK 1/FITC
产品编号： YB--0211R-FITC
产品价格： null
产品产地： 中国/美国
品牌商标： Ybscience
更新时间： 2023-08-17T10:29:50
使用范围： 科研使用
上海钰博生物科技有限公司
- 联系人 : 陈环环
- 地址 : 上海市沪闵路6088号龙之梦大厦8楼806室
- 邮编 : 200612
- 所在区域 : 上海
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- 传真 : 021-60514606
- 邮箱 : shybio@126.com
Anti-SHANK 1/FITC Conjugated抗体
| 产品编号 | YB-0211R-FITC |
| 英文名称 | Anti-SHANK 1/FITC |
| 中文名称 | FITC标记的富含脯氨酸突触相关蛋白SHANK1抗体 |
| 别 名 | GKAP/SAPAP interacting protein; SH3 and multiple ankyrin repeat domains 1; SH3 and multiple ankyrin repeat domains protein 1; SHANK-1; Somatostatin receptor interacting protein; Somatostatin receptor-interacting protein; SH3 and multiple ankyrin repeat domains protein 1; SPANK 1; SSTR-interacting protein; Shank1; SPANK1; SSTR interacting protein; SSTRIP; SHAN1_HUMAN; Synamon. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 225kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Shank1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The mechanisms underlying the molecular assemblage of molecules at the synapse are not well understood. Recently, a number of novel anchoring/scaffold proteins that are associated with postsynaptic density (PSD) proteins have been isolated. SHANK1, SHANK2 and SHANK3 constitute a family of proteins that may function as molecular scaffolds in the PSD. SHANK is made of five domain/regions that are probably involved in protein-protein interactions: ankyrin repeats, an SH3 domain, a PDZ domain, a SAM domain, and a proline rich region. SHANK interacts directly with GKAP or SAPAP via its PDZ domain, thus potentially bridging the N-methyl-D-aspartate receptor (NMDA)-PSD-95-GKAP complex. Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Subunit: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Subcellular Location: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD-95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2. Tissue Specificity: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously. Similarity: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain. Database links: Entrez Gene: 50944 Human Entrez Gene: 243961 Mouse Entrez Gene: 78957 Rat Omim: 604999 Human SwissProt: Q9Y566 Human SwissProt: D3YZU1 Mouse SwissProt: Q9WV48 Rat Unigene: 274255 Human Unigene: 360368 Mouse Unigene: 225968 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 有学者认为：shank-1似乎是具有兴奋性突触PSD中的连接蛋白，它可以连接后突触膜受体，包括NMDA-Type和谷氨酸受体等。在树突旋转和突触连接的有机体功能和结构方面起重要作用。shank1 主要表达在脑组织内，属于shank家族 |