Anti-PPAR delta + beta/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-PPAR delta + beta/FITC Conjugated抗体
英文名称: Anti-PPAR delta + beta/FITC
抗体货号: YB--0250R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from mouse PPAR-delta
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/6/14 14:07:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-PPAR delta + beta/FITC Conjugated抗体

产品编号 YB-0250R-FITC
英文名称 Anti-PPAR delta + beta/FITC
中文名称 FITC标记的D型-过氧化酶活化增生受体抗体
别    名 PPAR delta+beta; FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  免疫学  细胞膜受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse PPAR-delta
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.

Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous with maximal levels in placenta and skeletal muscle.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily. 
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 5467 Human

Entrez Gene: 19015 Mouse

Entrez Gene: 25682 Rat

Omim: 600409 Human

SwissProt: Q03181 Human

SwissProt: P35396 Mouse

Unigene: 696032 Human

Unigene: 328914 Mouse

Unigene: 96181 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

类固醇受体(Steroid Receptors)
研究人员指出该分子的功能,极可能就是阻断心血管免疫发炎反应的讯号传递过程。PPAR-delta基因是控制肌肉发展的重要基因,在增加老鼠耐力的同时还能帮助它燃烧掉脂肪,研究人员发现,对于与新陈代谢有关的各项疾病,从心脏病到肥胖症都有启发性的意义,他可以阻止脂肪沉淀在动脉壁上,进而防止动脉硬化症的发生,该蛋白参与脂肪代谢、肥胖、糖尿病、动脉硬化和癌症的发病。
在动脉硬化现象发生的早期,免疫细胞会促使血管慢性的发炎,因而造成血管不断地吸收和输送脂肪,进而导致脂肪的堆积与血管硬化,而PPAR-delta就像警卫分子一样,时时降低发炎反应和抑制动脉硬化斑的形成,因此该分子应该是相关药物研发,相当值得切入的目标。
研究人员认为,这个发现将给药厂研发治疗心血管疾病的新药提供新的线索

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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