Anti-Sema4C/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Sema4C/FITC Conjugated抗体

Anti-Sema4C/FITC Conjugated抗体

商家询价

产品名称: Anti-Sema4C/FITC Conjugated抗体

英文名称: Anti-Sema4C/FITC

产品编号: YB--1123R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
  • 联系人 : 陈环环
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  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-Sema4C/FITC Conjugated抗体

产品编号 YB-1123R-FITC
英文名称 Anti-Sema4C/FITC
中文名称 FITC标记的臂板蛋白4C抗体
别    名 Semaphorin 4C; Semaf; Semai; Semacl1; AI426163; mKIAA1739; Semaphorin F.FLJ20369; KIAA1739; M-SEMA-F; MGC126382; MGC126383; SEMACL1; SEMAI; SEM4C_HUMAN; M-SEMA-F; S4c; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C; SEMA4C; SEMACL1; SEMAF; SEMAI; Semaphorin-4C; UNQ5855/PRO34487.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Sema4C
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the semaphorin protein family are involved in axonal guidance during neural development. Semaphorin 5a is thought to have a bifunctional role in axon guidance, exerting both attractive and inhibitory effects on developing axons associated with limbic function. The thrombospondin repeats of Semaphorin 5a physically interact with both heparan sulfate proteoglycans and chondroitin sulfate proteoglycans, inducing attractive and inhibitory guidance cues, respectively. The biological responses to Semaphorin 5a are induced through binding to its high-affinity receptor, plexin B3, triggering intracellular signaling through Met.

Function:
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Subunit:
Interacts (via the PDZ-binding motif) with GIPC (via the PDZ domain) (By similarity). Interacts with NCDN (By similarity). Interacts (via the PDZ-binding motif) with DLG4. Interacts with PLXNB2 (By similarity).

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the semaphorin family. 
Contains 1 Ig-like C2-type (immunoglobulin-like) domain. 
Contains 1 PSI domain. 
Contains 1 Sema domain.

Database links:

Entrez Gene: 54910 Human

Omim: 604462 Human

SwissProt: Q9C0C4 Human

Unigene: 516220 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

一般认为:Sema4C及其相关蛋白在神经干细胞中表达比较多