Anti-PACAP-27/38/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-PACAP-27/38/FITC Conjugated抗体

Anti-PACAP-27/38/FITC Conjugated抗体

商家询价

产品名称: Anti-PACAP-27/38/FITC Conjugated抗体

英文名称: Anti-PACAP-27/38/FITC

产品编号: YB--0190R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-PACAP-27/38/FITC Conjugated抗体

产品编号 YB-0190R-FITC
英文名称 Anti-PACAP-27/38/FITC
中文名称 FITC标记的腺苷酸环化酶激活肽-27/38抗体
别    名 Adenylate Cyclase Activating Polypeptide 1 (Pituitary); Prepro-PACAP; PACAP; Pituitary Adenylate Cyclase Activating Polypeptide; PRP-48; PACAP27; PACAP38; ADCYAP1; PACA_HUMAN;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PACAP-27/38
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Function:
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).

Subunit:
Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

Subcellular Location:
Extracellular region or secreted

Similarity:
Belongs to the glucagon family.

Database links:

Entrez Gene: 116 Human

Entrez Gene: 11516 Mouse

Entrez Gene: 414283 Pig

Entrez Gene: 24166 Rat

Omim: 102980 Human

SwissProt: P18509 Human

SwissProt: O70176 Mouse

SwissProt: P41535 Pig

SwissProt: P13589 Rat

Unigene: 531719 Human

Unigene: 727476 Human

Unigene: 3407 Mouse

Unigene: 37400 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

腺苷酸环化酶激活肽是一种可激活垂体腺苷酸环化酶的多肽,有PACAP-27和 PACAP-38两种形式,他们共同具有N端27个氨基酸,属于PACAP/glucagon超级家族。在中枢神经系统分布广泛,其中以下丘脑含量最高