Anti-Nm23-H2/NME2/FITC Conjugated抗体上海钰博生物科技有限公司

金牌供应商

性能参数

产品名称: Anti-Nm23-H2/NME2/FITC Conjugated抗体
英文名称: Anti-Nm23-H2/NME2/FITC
抗体货号: YB--1073R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human Nm23
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/5/17 9:08:00
详细资料:  实验方法技术资料
浏览人数:16
诚信指数:1658点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
点此求购
在线QQ: 我是3002799160,请问我有什么可以帮到您呢?
生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

上海钰博生物科技有限公司
地址:
上海市沪闵路6088号龙之梦大厦8楼806室
邮编:
200612
电话:
021-60514606
传真:
021-60514606
联系人:
顾磊
所在区域:
上海·上海
邮件:
公司展台:
在线QQ:
我是3002799160,请问我有什么可以帮到您呢?
扫一扫,关注我们

产品详细描述

 Anti-Nm23-H2/NME2/FITC Conjugated抗体

产品编号 YB-1073R-FITC
英文名称 Anti-Nm23-H2/NME2/FITC
中文名称 FITC标记的肿瘤抑制基因NME2抗体
别    名 nucleoside dIPhosphatase kinase B; C myc purine binding transcription factor PUF; NDK B; NDKB; NDP kinase B; NDPKB; NM23 H2; NM23B; Nucleoside diphosphate kinase B; nm23-M2; NME2; Nucleoside diphosphate kinase alpha, p18-12d; puf; MGC107562; MGC107563; MGC111212; non-metastatic cells 2, protein (NM23B)expressed in; NDKB_HUMAN; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 17kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nm23
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
NM23 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined.

Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Subunit:
Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8. Interacts with AKAP13.

Subcellular Location:
Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the NDK family.

Database links:

Entrez Gene: 395916 Chicken

Entrez Gene: 480559 Dog

Entrez Gene: 4831 Human

Entrez Gene: 654364 Human

Entrez Gene: 18103 Mouse

Entrez Gene: 83782 Rat

Omim: 156491 Human

SwissProt: Q3T0Q4 Cow

SwissProt: Q50KA8 Dog

SwissProt: P22392 Human

SwissProt: Q01768 Mouse

SwissProt: Q2EN76 Pig

SwissProt: P19804 Rat

Unigene: 463456 Human

Unigene: 1260 Mouse

Unigene: 927 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

Nm23-H2在高转移性的肿瘤中呈现低表达,提示NM23-H2具有转移抑制的功能。其抑制肿瘤转移机制为增强微丝、微管的聚合,影响细胞的移动,从而抑制肿瘤的侵袭和转移

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

查看Anti-Nm23-H2/NME2/FITC Conjugated抗体产品的用户还对以下产品感兴趣

暂无

ADVERTISEMENT

找不到您所需的产品,发布求购试试?

标题:*
描述:
姓名:*
Email:*
单位:*
电话:*
地址:*
邮编:
资料: 需要 不需要
报价: 需要 不需要