Anti-Manic Fringe/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Manic Fringe/FITC Conjugated抗体

Anti-Manic Fringe/FITC Conjugated抗体

商家询价

产品名称: Anti-Manic Fringe/FITC Conjugated抗体

英文名称: Anti-Manic Fringe/FITC

产品编号: YB--12390R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

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 Anti-Manic Fringe/FITC Conjugated抗体

产品编号 YB-12390R-FITC
英文名称 Anti-Manic Fringe/FITC
中文名称 FITC标记的狂躁基因同源蛋白MFNG抗体
别    名 3-N-acetylglucosaminyltransferase manic fringe; Beta-1; Beta-1,3-N-acetylglucosaminyltransferase manic fringe; MFNG; MFNG_HUMAN; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep, Chimpanzee, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Manic Fringe/MFNG
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Radical fringe plays a key role in the development of the limb bud. Lunatic fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice.

Function:
Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity.

Subcellular Location:
Golgi apparatus membrane.

Similarity:
Belongs to the glycosyltransferase 31 family.

Database links:

Entrez Gene: 4242 Human

Entrez Gene: 17305 Mouse

Entrez Gene: 315119 Rat

Omim: 602577 Human

SwissProt: O00587 Human

SwissProt: O09008 Mouse

Unigene: 517603 Human

Unigene: 149235 Mouse

Unigene: 102109 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications