Anti-Alx1/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Alx1/FITC Conjugated抗体

Anti-Alx1/FITC Conjugated抗体

商家询价

产品名称: Anti-Alx1/FITC Conjugated抗体

英文名称: Anti-Alx1/FITC

产品编号: YB--12356R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-Alx1/FITC Conjugated抗体

产品编号 YB-12356R-FITC
英文名称 Anti-Alx1/FITC
中文名称 FITC标记的软骨蛋白1抗体
别    名 ALX homeobox 1; ALX homeobox protein 1; ALX1; ALX1_HUMAN; CART 1; CART-1; CART1; Cartilage homeoprotein 1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  干细胞  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CART1/Alx1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008]. 

Function:
Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development.

Subunit:
Interacts (via homeobox domain) with EP300.

Subcellular Location:
Nucleus.

Tissue Specificity:
Cartilage and cervix tissue.

Post-translational modifications:
Acetylated at Lys-131 by EP300, leading to increased interaction with EP300 and enhances transcriptional activation activity.

DISEASE:
Defects in ALX1 are the cause of frontonasal dysplasia type 3 (FND3) [MIM:613456]. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.

Similarity:
Belongs to the paired homeobox family. 
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 8092 Human

Omim: 601527 Human

SwissProt: Q15699 Human

Unigene: 41683 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications