Anti-phospho-KIF20A (Ser528)/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-phospho-KIF20A (Ser528)/FITC Conjugated抗体

Anti-phospho-KIF20A (Ser528)/FITC Conjugated抗体

商家询价

产品名称: Anti-phospho-KIF20A (Ser528)/FITC Conjugated抗体

英文名称: Anti-phospho-KIF20A (Ser528)/FITC

产品编号: YB--17045R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-phospho-KIF20A (Ser528)/FITC Conjugated抗体

产品编号 YB-17045R-FITC
英文名称 Anti-phospho-KIF20A (Ser528)/FITC
中文名称 FITC标记的磷酸化有丝分裂驱动蛋白样2抗体
别    名 KIF20A (phospho S528); p-KIF20A (phospho S528); GG10 2; GG10_2; Kif20a; kinesin family member 20A; Kinesin like protein KIF20A; Kinesin-like protein 174; mitotic kinesin like protein 2; MKLP2; RAB6 interacting, kinesin like (rabkinesin6); Rab6-interacting kinesin-like protein; RAB6-INTERACTING PROTEIN, KINESIN-LIKE; RAB6KIFL; Rabkinesin 6; AA415432; FLJ21151.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Rat, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human KIF20A around the phosphorylation site of Ser528
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell (1-3). Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis (3,4). KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons (5). Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle (5). Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum (5). KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta (6). In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance (7).

Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Subcellular Location:
Golgi apparatus. Cytoplasm > cytoskeleton > spindle.

Post-translational modifications:
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.

Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.

Database links:

Entrez Gene: 10112 Human

Entrez Gene: 19348 Mouse

Omim: 605664 Human

SwissProt: O95235 Human

SwissProt: P97329 Mouse

Unigene: 718626 Human

Unigene: 258846 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.