Anti-LCT/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-LCT/FITC Conjugated抗体

Anti-LCT/FITC Conjugated抗体

商家询价

产品名称: Anti-LCT/FITC Conjugated抗体

英文名称: Anti-LCT/FITC

产品编号: YB--18200R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
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 Anti-LCT/FITC Conjugated抗体

产品编号 YB-18200R-FITC
英文名称 Anti-LCT/FITC
中文名称 FITC标记的乳糖酶根皮苷水解酶1抗体
别    名 LAC; Lactase; Lactase phlorizin hydrolase 1; Lactase phlorizin hydrolase; Lactase-glycosylceramidase; Lct; LPH; LPH_HUMAN; LPH1; Phlorizin hydrolase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 121kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LCT
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq, Jul 2008]

Function:
LPH splits lactose in the small intestine.

Subcellular Location:
Apical cell membrane. Brush border.

Tissue Specificity:
Intestine.

DISEASE:
Defects in LCT are the cause of congenital lactase deficiency (COLACD) [MIM:223000]; also known as hereditary alactasia or disaccharide intolerance II. Congenital lactase deficiency is a an autosomal recessive, rare and severe gastrointestinal disorder. It is characterized by watery diarrhea in infants fed with breast milk or other lactose-containing formulas. An almost total lack of LCT activity is found in jejunal biopsy material of patients with congenital lactase deficiency. Opposite to congenital lactase deficiency, adult-type hypolactasia, also known as lactose intolerance, is the most common enzyme deficiency worldwide. It is caused by developmental down-regulation of lactase activity during childhood or early adulthood. The decline of lactase activity is a normal physiological phenomenon; however, the majority of Northern Europeans have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence). The down-regulation of lactase activity operates at the transcriptional level and it is associated with a noncoding variation in the MCM6 gene, located in the upstream vicinity of LCT.

Similarity:
Belongs to the glycosyl hydrolase 1 family.

Database links:

Entrez Gene: 3938 Human

Omim: 603202 Human

SwissProt: P09848 Human

Unigene: 551506 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications