Anti-AMPK beta 2/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-AMPK beta 2/FITC Conjugated抗体
英文名称: Anti-AMPK beta 2 /FITC
抗体货号: YB--20238R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human AMPK beta 2
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/11 11:35:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-AMPK beta 2/FITC Conjugated抗体

产品编号 YB-20238R-FITC
英文名称 Anti-AMPK beta 2 /FITC
中文名称 FITC标记的腺苷单***酸活化蛋白激酶β2抗体
别    名 AAKB2_HUMAN; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2.   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AMPK beta 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges 

Subunit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).

Tissue Specificity:
Highly expressed in kidney, heart, white adipose tissue, lung and spleen.

Post-translational modifications:
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.

Similarity:
Belongs to the 5'-AMP-activated protein kinase beta subunit family. 

Database links:

Entrez Gene: 5565 Human

Entrez Gene: 108097 Mouse

Entrez Gene: 64562 Rat

Omim: 602741 Human

SwissProt: O43741 Human

SwissProt: Q6PAM0 Mouse

SwissProt: Q9QZH4 Rat

Unigene: 50732 Human

Unigene: 31175 Mouse

Unigene: 207202 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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