Anti-NIPA1/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-NIPA1/FITC Conjugated抗体
英文名称: Anti-NIPA1/FITC
抗体货号: YB--19250R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human NIPA1
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/11 12:03:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-NIPA1/FITC Conjugated抗体

产品编号 YB-19250R-FITC
英文名称 Anti-NIPA1/FITC
中文名称 FITC标记的NIPA1蛋白抗体
别    名 FSP 3; FSP3; Magnesium transporter NIPA1; MGC102724; MGC35570; NIPA 1; NIPA1; NIPA1_HUMAN; Non imprinted in Prader Willi/Angelman syndrome region protein 1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1; Spastic paraplegia 6 (autosomal dominant); Spastic paraplegia 6 protein; SPG 6; SPG6.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 35kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIPA1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008]

Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).

Subcellular Location:
Cell membrane. Early endosome. Recruited to the cell membrane in response to low extracellular magnesium.

Tissue Specificity:
Widely expressed with highest levels in neuronal tissues.

DISEASE:
Defects in NIPA1 are the cause of spastic paraplegia autosomal dominant type 6 (SPG6) [MIM:600363]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

Similarity:
Belongs to the NIPA family.

Database links:

Entrez Gene: 123606 Human

Entrez Gene: 233280 Mouse

Entrez Gene: 308668 Rat

Omim: 608145 Human

SwissProt: Q7RTP0 Human

SwissProt: Q8BHK1 Mouse

Unigene: 511797 Human

Unigene: 389901 Mouse

Unigene: 443911 Mouse

Unigene: 48451 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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