Anti-Nexilin/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-Nexilin/FITC Conjugated抗体
英文名称: Anti-Nexilin/FITC
抗体货号: YB--19222R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human Nexilin
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/12 8:38:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-Nexilin/FITC Conjugated抗体

产品编号 YB-19222R-FITC
英文名称 Anti-Nexilin/FITC
中文名称 FITC标记的F-肌动蛋白结合蛋白抗体
别    名 1110046H09Rik; AA553326; F-actin binding protein; F-actin-binding protein; MGC104234; MGC138865; MGC138866; Nelin; Nexilin; Nexn; NEXN_HUMAN; nF actin binding protein; OTTHUMP00000038336.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  信号转导  结合蛋白  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nexilin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Function:
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.

Subcellular Location:
Cytoplasm; cytoskeleton. Cell junction; adherens junction. Cytoplasm; myofibril > sarcomere; Z line. Localizes to the cell-matrix AJ. Not found at the cell-cell AJ.

Tissue Specificity:
Abundantly expressed in heart and skeletal muscle, and at lower levels in placenta, lung, liver and pancreas. Also expressed in HeLa S3 and Molt-4 cells.

DISEASE:
Defects in NEXN are the cause of cardiomyopathy dilated type 1CC (CMD1CC) [MIM:613122]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Defects in NEXN are the cause of cardiomyopathy familial hypertrophic type 20 (CMH20) [MIM:613876]. CMH20 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Similarity:
Contains 1 Ig-like (immunoglobulin-like) domain.

Database links:

Entrez Gene: 91624 Human

Entrez Gene: 68810 Mouse

Entrez Gene: 246172 Rat

Omim: 613121 Human

SwissProt: Q0ZGT2 Human

SwissProt: Q7TPW1 Mouse

SwissProt: Q9Z2J4 Rat

Unigene: 612385 Human

Unigene: 200188 Mouse

Unigene: 107975 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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