Anti-PRPK/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-PRPK/FITC Conjugated抗体
英文名称: Anti-PRPK/FITC
抗体货号: YB--19406R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human PRPK
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/12 10:53:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-PRPK/FITC Conjugated抗体

产品编号 YB-19406R-FITC
英文名称 Anti-PRPK/FITC
中文名称 FITC标记的TP53调节激酶抗体
别    名 C20orf64; Nori 2; Nori 2p; Nori-2; p53 related protein kinase; p53-related protein kinase; PRPK_HUMAN; TP53 regulating kinase; TP53-regulating kinase; TP53RK.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PRPK
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
PRPK is a 253 amino acid protein kinase that phosphorylates Ser15 of p53. PRPK phosphorylation of p53 causes increased stabilization and activity of p53. CGI-121 may act as an inhibitor of the PRPK-p53 interaction, thus preventing the phosphorylation of p53. Unphosphorylated p53 is degraded by the ubiquitin-proteasome pathway, which may ultimately lead to cell proliferation. PRPK contains a protein kinase domain with a conserved catalytic core. PRPK is localized to the nucleus of the cell and is highly expressed in testis, with lower expression in heart, kidney and spleen.

Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis. Weakly expressed in heart kidney and spleen.

Similarity:
Belongs to the protein kinase superfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 112858 Human

Entrez Gene: 76367 Mouse

Omim: 608679 Human

SwissProt: Q96S44 Human

SwissProt: Q99PW4 Mouse

Unigene: 440263 Human

Unigene: 330796 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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