Anti-phospho-IRS-2(Ser731)/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-phospho-IRS-2(Ser731)/FITC Conjugated抗体
英文名称: Anti-phospho-IRS-2(Ser731)/FITC
抗体货号: YB--10998R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated Synthesised phosphopeptide derived from human IRS-2 around the phosphorylation site of Ser731
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: Human, Mouse, Rat, Dog, Horse,
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/12 11:38:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-phospho-IRS-2(Ser731)/FITC Conjugated抗体

产品编号 YB-10998R-FITC
英文名称 Anti-phospho-IRS-2(Ser731)/FITC
中文名称 FITC标记的***酸化胰岛素受体底物2抗体
别    名 IRS-2(phospho-Ser731); IRS-2(phospho S731); *** Receptor Substrate 2; IRS 2; IRS-2; IRS2; IRS2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 心血管  细胞生物  免疫学  神经生物学  信号转导  生长因子和***  转录调节因子  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 147kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human IRS-2 around the phosphorylation site of Ser731
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The family of insulin receptor substrates (IRSs) has been reported to play important roles for signal transduction of various hormones. Four members of the IRS family have been described. Each IRS is believed to have different functions; however, the distinct physiological roles of each IRS are unclear. Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Function:
May mediate the control of various cellular processes by insulin.

Subunit:
Interacts with PHIP.

Subcellular Location:
Cytoplasm, cytosol.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 IRS-type PTB domain. 
Contains 1 PH domain.

Database links:

Entrez Gene: 8660 Human

Entrez Gene: 384783 Mouse

Entrez Gene: 29376 Rat

Omim: 600797 Human

SwissProt: Q9Y4H2 Human

SwissProt: P81122 Mouse

Unigene: 442344 Human

Unigene: 407207 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

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