Anti-Periplakin/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Periplakin/FITC Conjugated抗体

Anti-Periplakin/FITC Conjugated抗体

商家询价

产品名称: Anti-Periplakin/FITC Conjugated抗体

英文名称: Anti-Periplakin/FITC

产品编号: YB--0350R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

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 Anti-Periplakin/FITC Conjugated抗体

产品编号 YB-0350R-FITC
英文名称 Anti-Periplakin/FITC
中文名称 FITC标记的周斑蛋白抗体
别    名 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 205kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Periplak
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

Subcellular Location:
Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.

Tissue Specificity:
Expressed in stratified squamous epithelia and in some other epithelia.

Similarity:
Belongs to the plakin or cytolinker family.
Contains 2 plectin repeats.
Contains 4 spectrin repeats.

Database links:

Entrez Gene: 5493 Human

Entrez Gene: 19041 Mouse

Entrez Gene: 302934 Rat

Omim: 602871 Human

SwissProt: O60437 Human

SwissProt: Q9R269 Mouse

Unigene: 192233 Human

Unigene: 266875 Mouse

Unigene: 25259 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications