Anti-Dystrobrevin alpha/FITC Conjugated抗体-抗体-抗体-生物在线
Anti-Dystrobrevin alpha/FITC Conjugated抗体

Anti-Dystrobrevin alpha/FITC Conjugated抗体

商家询价

产品名称: Anti-Dystrobrevin alpha/FITC Conjugated抗体

英文名称: Anti-Dystrobrevin alpha/FITC

产品编号: YB--23134R-FITC

产品价格: null

产品产地: 中国/美国

品牌商标: Ybscience

更新时间: 2023-08-17T10:29:50

使用范围: 科研使用

上海钰博生物科技有限公司
  • 联系人 : 陈环环
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  • 邮编 : 200612
  • 所在区域 : 上海
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  • 邮箱 : shybio@126.com

 Anti-Dystrobrevin alpha/FITC Conjugated抗体

产品编号 YB-23134R-FITC
英文名称 Anti-Dystrobrevin alpha/FITC
中文名称 FITC标记的肌营养蛋白α抗体
别    名 DRP3; DTN; DTNA; Dystrophin related protein 3; FLJ96209; LVNC1; OTTHUMP00000163154; OTTHUMP00000163155; D18S892E; DTN-A; DTNA_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Dog, Horse, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 81kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Dystrobrevin alpha
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Dystrobrevin alpha belongs to the dystrobrevin subfamily of the dystrophin family. It is a component of the dystrophin associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha and beta dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin alpha may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Mutations in Dystrobrevin alpha are associated with left ventricular noncompaction with congenital heart defects.

Function:
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration .

Subunit:
Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

Subcellular Location:
Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.

Tissue Specificity:
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Post-translational modifications:
Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.

Similarity:
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Database links:

Entrez Gene: 1837 Human

Entrez Gene: 13527 Mouse

Omim: 601239 Human

SwissProt: Q9Y4J8 Human

SwissProt: Q9D2N4 Mouse

Unigene: 643454 Human

Unigene: 94371 Mouse

 


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.