Anti-UBR4/FITC Conjugated抗体上海钰博生物科技有限公司

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产品名称: Anti-UBR4/FITC Conjugated抗体
英文名称: Anti-UBR4/FITC
抗体货号: YB--17092R-FITC
产品规格: 20ul/50ul/100ul/200ul
级    别: , 分析纯, 见说明书
产品产地: 中国/美国
品牌商标: Ybscience
价    格: 2980元
抗原: KLH conjugated synthetic peptide derived from human UBR4
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
见说明书conjugate:见说明书
Isotype:见说明书
应用范围: 科研使用
更新时间: 2019/7/25 9:57:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Anti-UBR4/FITC Conjugated抗体

产品编号 YB-17092R-FITC
英文名称 Anti-UBR4/FITC
中文名称 FITC标记的E3泛素蛋白连接酶UBR4抗体
别    名 Ubiquitin Protein Ligase E3 Component N-Recognin 4; Retinoblastoma-Associated Factor Of 600 KDa; Zinc Finger UBR1-Type Protein 1; N-Recognin-4; RBAF600; ZUBR1; P600; Retinoblastoma-Associated Factor 600-Like Protein; 600 KDa Retinoblastoma Protein-Associated Factor; E3 Ubiquitin-Protein Ligase UBR4; Zinc Finger, UBR1 Type 1; EC 6.3.2.-; KIAA0462 KIAA1307; EC 6.3.2; GC01M019074; UBR4_HUMAN;   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  细胞骨架  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应  
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 574kDa
性    状 Lyophilized or Liquid
浓    度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBR4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Subunit:
Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.

Subcellular Location:
Membrane Curated; Multi-pass membrane protein; Cytoplasm; cytoskeleton; Nucleus

Similarity:
Belongs to the UBR4 family.

Database links:

HGNC: 30313

Entrez Gene: 23352

Ensembl: ENSG00000127481

OMIM: 609890

UniProtKB: Q5T4S7



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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