Anti-CBLN1 Polyclonal Antibody北京索莱宝科技有限公司

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性能参数

产品名称: Anti-CBLN1 Polyclonal Antibody
英文名称: Anti-CBLN1 Polyclonal Antibody
抗体货号: K107418P
产品规格: 50ul/100ul
级    别: ,
产品产地: 北京
品牌商标: Solarbio
价    格: 900/50ul;1600/100ul元
抗原: A synthetic peptide of human CBLN1
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse Rat
应用范围: IHC
更新时间: 2019/9/6 14:55:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
18435223305
传真:
010-56371281
联系人:
郭倩
所在区域:
北京·北京
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公司展台:
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产品详细描述

 

Anti-CBLN1 Polyclonal Antibody 

品牌:Solarbio | 货号:K107418P

商品货号:商品品牌:规格基本售价:选择规格
K107418P-50ulSolarbio50ul960.00元
K107418P-100ulSolarbio100ul1600.00元
英文名称Anti-CBLN1 Polyclonal Antibody
宿主Rabbit
别名CER
应用IHC
稀释比例IHC 1:50-200.
交叉反应Human Mouse Rat
蛋白分子量21kDa
Gene ID869
保存Store at -20°C. Avoid freeze / thaw cycles.
储存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法Affinity purification
亚型IgG
免疫原A synthetic peptide of human CBLN1
Subcellular
Locations
Cell membrane Cytoplasm 
Swiss ProtP23435
克隆类型Polyclonal Antibody
背景资料"Required for synapse integrity and synaptic plasticity.
During cerebellar synapse formation, essential for the
matching and maintenance of pre- and post-synaptic
elements at parallel fiber-Purkinje cell synapses, the
establishment of the proper pattern of climbing fiber-
Purkinje cell innervation, and induction of long-term
depression at parallel fiber-Purkinje cell synapses. Plays a
role as a synaptic organizer that acts bidirectionally on
both pre- and post-synaptic components. On the one
hand induces accumulation of synaptic vesicles in the pre-
synaptic part by binding with NRXN1 and in other hand
induces clustering of GRID2 and its associated proteins at
the post-synaptic site through association of GRID2.
NRXN1-CBLN1-GRID2 complex directly induces parallel
fiber protrusions that encapsulate spines of Purkinje cells
leading to accumulation of GRID2 and synaptic vesicles.
Required for CBLN3 export from the endoplasmic
reticulum and secretion (By similarity). NRXN1-CBLN1-
GRID2 complex mediates the D-Serine-dependent long
term depression signals and AMPA receptor endocytosis.

The cerebellin peptide exerts neuromodulatory functions.
Directly stimulates norepinephrine release via the
adenylate cyclase/PKA-dependent signaling pathway; and
indirectly enhances adrenocortical secretion in vivo,
through a paracrine mechanism involving medullary
catecholamine release (By similarity).

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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