Trastuzumab; Anti-Human HER2; Humanized Antibody上海皓元生物医药科技有限公司

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产品名称: Trastuzumab; Anti-Human HER2; Humanized Antibody
英文名称: 曲妥珠单抗;曲妥单抗;群司珠单抗
抗体货号: HY-P9907
产品规格: 5 mg
产品产地: 美国
品牌商标: MedChemExpress (MCE)
价    格: 5500元
抗原来源: 
抗体来源: 
适用物种: 
应用范围: 
更新时间: 2019/11/7 9:28:00
详细资料:  实验方法技术资料
浏览人数:4
诚信指数:1000点
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使用范围:仅限科研使用,不能应用于临床
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上海皓元生物医药科技有限公司
地址:
上海市浦东新区张衡路1999弄3号楼
邮编:
201203
电话:
021-58955995
传真:
021-53700325
联系人:
销售部
所在区域:
上海·上海
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产品详细描述

Trastuzumab

MCE 国际站:Trastuzumab

产品活性:Trastuzumab 是一种人源化单克隆抗体,其以高亲和力与 HER2 选择性结合。Trastuzumab 已被批准用于治疗 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌。

研究领域:Protein Tyrosine Kinase/RTK  |  JAK/STAT Signaling

作用靶点:EGFR

In Vitro: Treatment of HER2-overexpressing breast cancer cell lines with Trastuzumab results in induction of p27KIP1 and the Rb-related protein, p130, which in turn significantly reduces the number of cells undergoing S-phase. A number of other phenotypic changes are observed in vitro as a consequence of Trastuzumab binding to HER2-overexpressing cells. Interaction of Trastuzumab with the human immune system via its human immunoglobulin G1 Fc domain may potentiate its antitumor activities. in vitro studies demonstrate that Trastuzumab is very effective in mediating antibody-dependent cell-mediated cytotoxicity against HER2-overexpressing tumor targets. Trastuzumab consists of two antigen-specific sites that bind to the juxtamembrane portion of the extracellular domain of the HER2 receptor and that prevent the activation of its intracellular tyrosine kinase. Trastuzumab recruits immune effector cells that are responsible for antibody-dependent cytotoxicity. The presence of Trastuzumab IgG significantly increases killing of all breast cancer cell lines. The ADCC activity of PBMCs evoked by Trastuzumab is equally strong against Trastuzumab-sensitive (SKBR-3) or Trastuzumab-resistant (JIMT-1) breast cancer cells, with dose-dependent cell death reaching 5060% killing at an effector/target ratio of 60:1.

In Vivo: Trastuzumab treatment of mouse xenograft models results in marked suppression of tumor growth. When given in combination with standard cytotoxic chemotherapeutic agents, Trastuzumab treatment generally results in statistically superior antitumor efficacy compared with either agent given alone. Trastuzumab causes a significant growth inhibition of the outgrowth of macroscopic JIMT-1 xenograft tumors in both nude and SCID mice.

相关产品:Osimertinib  |  Gefitinib  |  Afatinib  |  Erlotinib  |  AG-490  |  Lapatinib  |  Cetuximab  |  Genistein  |  Neratinib  |  AG-1478  |  Dacomitinib  |  Poziotinib  |  Sapitinib  |  Pyrotinib  |  TAS6417  |  Tucatinib  |  Mubritinib  |  BMS-690514  |  Canertinib dihydrochloride  |  Icotinib  |  Pertuzumab  |  Olmutinib  |  AZ-5104  |  Pelitinib  |  AZD3759

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物;
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;
•   设有专业的实验中心和严格的质控、验证体系;
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
•   产品的生物活性多经各国客户实验验证;
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
•   专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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