Obinutuzumab; GA101; GA-101; Anti-Human CD20 type II; Humanized Antibody上海皓元生物医药科技有限公司

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产品名称: Obinutuzumab; GA101; GA-101; Anti-Human CD20 type II; Humanized Antibody
英文名称: 奥滨尤妥珠单抗;阿托珠单抗
抗体货号: HY-P9910
产品规格: 5 mg
产品产地: 美国
品牌商标: MedChemExpress (MCE)
价    格: 26600元
抗原来源: 
抗体来源: 
适用物种: 
应用范围: 
更新时间: 2019/11/7 9:28:00
详细资料:  实验方法技术资料
浏览人数:7
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使用范围:仅限科研使用,不能应用于临床
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上海皓元生物医药科技有限公司
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产品详细描述

Obinutuzumab

MCE 国际站:Obinutuzumab

产品活性:Obinutuzumab (GA101) 是新型糖工程化II型CD20单克隆抗体,开发用来治疗非霍奇金淋巴瘤。

研究领域:Others

作用靶点:Others

In Vitro: Obinutuzumab is found to be superior to rituximab and ofatumumab in the induction of direct cell death (independent of mechanical manipulation required for cell aggregate disruption formed by antibody treatment), whereas it is 10 to 1,000 times less potent in mediating CDC. Obinutuzumab shows superior activity to rituximab and ofatumumab in ADCC and whole-blood B-cell depletion assays, and is comparable with these two in ADCP. Obinutuzumab also shows slower internalization rate upon binding to CD20 than rituximab and ofatumumab

In Vivo: Obinutuzumab is more active than rituximab administered at similar doses on established RL tumors. The antitumor effect of obinutuzumab against RL xenografts is dose dependent in terms of tumor growth inhibition (TGI). TGI is calculated using NCI formula at day 34 and shows values of 25, 75, and 85% for the 10, 30, and 100 mg/kg dosages of obinutuzumab, respectively. The higher doses of 30 and 100 mg/kg of obinutuzumab significantly inhibit the growth of RL tumors and result in some complete tumor remissions (10% and 30%, respectively). Tolerability of obinutuzumab with these regimens is excellent and no significant modification of body weight is observed. Obinutuzumab induces a strong antitumor effect, including complete tumor remission in the SU-DHL4 model and overall superior efficacy compared with both rituximab and ofatumumab. Obinutuzumab plus bendamustine achieves superior tumor growth inhibition versus rituximab plus bendamustine and shows a statistically significant effect versus the respective single treatments. Obinutuzumab plus chemotherapy is superior to the respective monotherapies.

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品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物;
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•   产品的生物活性多经各国客户实验验证;
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•   专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
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