Anti-Jak1 Monoclonal Antibody-抗体-抗体-生物在线
Anti-Jak1 Monoclonal Antibody

Anti-Jak1 Monoclonal Antibody

商家询价

产品名称: Anti-Jak1 Monoclonal Antibody

英文名称: Anti-Jak1 Monoclonal Antibody

产品编号: K000064M

产品价格: null

产品产地: 北京市通州区马驹桥

品牌商标: solarbio

更新时间: 2023-08-11T10:26:26

使用范围: WB IP

北京索莱宝科技有限公司
  • 联系人 : 索莱宝-龚思雨
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Anti-Jak1 Monoclonal Antibody

品牌:solarbio | 货号:K000064M

 

英文名称 Anti-Jak1 Monoclonal Antibody
宿主 Mouse
别名 JAK1A;JAK1B;JTK3;Janus kinase 1
应用 WB IP
稀释比例 WB 1:500.
蛋白分子量 133kDa
Gene ID 3716
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 Purified recombinant human Jak1 protein fragments expressed in E.coli.
性状 液体
Public Immunogen Range Purified recombinant human Jak1 protein fragments expressed in E.coli.
Subcellular Locations Endomembrane system Peripheral membrane protein
Swiss Prot P23458
克隆号 7B1-B6-G7
克隆类型 Monoclonal Antibody
背景资料 Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.