Anti-ErbB2 Monoclonal Antibody

品牌：solarbio | 货号：K000166M

宿主	Mouse
英文名称	Anti-ErbB2 Monoclonal Antibody
别名	CD340;HER-2;HER-2/neu;HER2;MLN19;NEU;NGL;TKR1
应用	WB
稀释比例	WB 1:1000.
蛋白分子量	138kDa
Gene ID	2064
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human ErbB2 protein fragments expressed in E.coli.
性状	液体
Subcellular Locations	Cell membrane Cytoplasm Nucleus Nucleus Single-pass type I membrane protein perinuclear region
Swiss Prot	P04626
克隆号	5B6-A9-C8
克隆类型	Monoclonal Antibody
背景资料	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]