Anti-TLR3 单克隆抗体
产品名称: Anti-TLR3 单克隆抗体
英文名称: Anti-TLR3 Monoclonal Antibody
产品编号: K000177M
产品价格: null
产品产地: 北京市通州区马驹桥
品牌商标: Solarbio
更新时间: 2023-08-11T10:26:26
使用范围: WB
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
- 电话 : 178****1073
- 传真 :
- 邮箱 : 3193328036@qq.com
Anti-TLR3 Monoclonal Antibody
品牌:solarbio | 货号:K000177M
宿主 | Mouse |
---|---|
英文名称 | Anti-TLR3 Monoclonal Antibody |
别名 | CD283;IIAE2;Toll-like receptor 3 |
应用 | WB |
稀释比例 | WB 1:1000. |
蛋白分子量 | 73/104kDa |
Gene ID | 7098 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 | Affinity purification |
亚型 | IgG2b |
免疫原 | Purified recombinant human TLR3 protein fragments expressed in E.coli. |
性状 | 液体 |
Subcellular Locations | Early endosome Endoplasmic reticulum membrane Endosome membrane Single-pass type I membrane protein |
Swiss Prot | O15455 |
克隆号 | 2F10-B8-G9 |
克隆类型 | Monoclonal Antibody |
背景资料 | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. |