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Cetuximab
CAS No. : 205923-56-4
MCE 国际站：Cetuximab
产品活性：Cetuximab 是一种单克隆抗体，能够抑制 EGFR，SPR 方法测得 Cetuximab 对可溶性 EGFR 的 Kd 值为 0.201 nM；Cetuximab 具有高效的抗肿瘤作用。
研究领域：Protein Tyrosine Kinase/RTK | JAK/STAT Signaling
作用靶点：EGFR
In Vitro: Cetuximab (C225) is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for soluble EGFR by SPR. Cetuximab also exhibits a Kd of 0.147 nM for EGFR in fixed A431 cells by ELISA. Cetuximab (C225; 30 nM) time-dependently inhibits the proliferation of SCC-1, SCC-11B, SCC-38, and SCC-13Y cells after treatment for 8 d. Cetuximab (30 nM) causes G0/G1 arrest, induces apoptosis, and reduces Rb, p27KIP1, Bcl-2, and Bax expression in SCC-13Y cells. Cetuximab (30 nM) also enhances radiosensitivity and increases radiation-induced apoptosis in SCC-13Y cells.
In Vivo: Cetuximab (1mg/injection) has effect on the tumour volume but the effect is more pronounced on UT-SCC-14 xenografts. In UT-SCC-14 xenografts, Cetuximab treatment significantly reduces the expression of EGFR, pEGFR and Ki67. The MCT1 and GLUT1 expression is significantly decreased in the Cetuximab-treated groups of both cell lines but differences are more pronounced in UT-SCC-14 xenografts.
相关产品：Gefitinib | Osimertinib | Erlotinib | Afatinib | AG-490 | Trastuzumab | Lapatinib | Neratinib | Genistein | AG-1478 | Poziotinib | Dacomitinib | Sapitinib | Pyrotinib | TAS6417 | Tucatinib | Mubritinib | Pertuzumab | Icotinib | BMS-690514 | AZD3759 | Canertinib dihydrochloride | BI-4020 | Lazertinib | AZ-5104
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