Anti-DAPK3 Polyclonal Antibody北京索莱宝科技有限公司

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性能参数

产品名称: Anti-DAPK3 Polyclonal Antibody
英文名称: Anti-DAPK3 Polyclonal Antibody
抗体货号: K108688P
产品规格: 
产品产地: 北京
品牌商标: Solarbio
价    格: 询价
抗原来源: 
抗体来源: Rabbit
适用物种: Human Mouse Rat
应用范围: WB IHC
更新时间: 2021/1/15 15:13:00
详细资料:  实验方法技术资料
浏览人数:38
诚信指数:1451点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

北京索莱宝科技有限公司
地址:
北京市通州区马驹桥镇联东U谷景盛南四街15号85A三层
邮编:
101102
电话:
010-50973129
传真:
010-56371281
联系人:
张净花
所在区域:
北京·北京
邮件:
公司展台:
在线QQ:
我是405465416,请问我有什么可以帮到您呢?
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产品详细描述

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. 

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