Anti-PPP1A-抗体-抗体-生物在线
Anti-PPP1A

Anti-PPP1A

商家询价

产品名称: Anti-PPP1A

英文名称:

产品编号: 200225

产品价格: null

产品产地: 成都正能生物

品牌商标: Zen BioScience

更新时间: null

使用范围: WB,IHC,ICC

成都正能生物技术有限责任公司
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  • 地址 : 中国成都高新区科园南路爱斯特大厦
  • 邮编 : 610200
  • 所在区域 : 四川
  • 电话 : 180****2350
  • 传真 : +86-028-85739596
  • 邮箱 : sales@zen-bioscience.com

Size  100ug

Cat code  200225

Species Cross-reactivity  H

Key Application  WB,IHC,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG1

Molecular Weight  38kDa

Sensitivity  This antibody detects endogenous levels of PPP1CA and does not cross-react with related proteins.

Immunogen  Purified recombinant human PPP1CA protein fragments expressed in E.coli.

UniProt Number  P62136

GeneBank ID  NM_001008709

Subcellular location  Cytoplasm. Nucleus. Nucleus

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol

Altername  serine/threonine-protein phosphatase PP1-alpha catalytic subunit;protein phosphatase 1; catalytic subunit, alpha isoform;serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit;Protein Phosphatase 1 alpha;PPP1CA

Gene_symbol  PP-1A; PPP1A; PP1alpha

Summary  The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniPort summary Function  Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.

Application Images :  

Western blot detection of PPP1CA in MCF7 , K562 ,Hela ,HEPG2 &Jurkat Whole cell lysates using PPP1CA antibody (1:1000 diluted). Predicted band size: 38KDa Observed band size: 38KDa

Immunocytochemistry stain of Hela using PPP1CA antibody (1:300).

IHC of paraffin-embedded human breast cancer using anti- PPP1CA diluted 1/500-1/1000.