PeproTech Armenian Hamster抗小鼠CD279 (PD-1) SAFIRE (Functional)-抗体-抗体-生物在线
PeproTech Armenian Hamster抗小鼠CD279 (PD-1) SAFIRE (Functional)

PeproTech Armenian Hamster抗小鼠CD279 (PD-1) SAFIRE (Functional)

商家询价

产品名称: PeproTech Armenian Hamster抗小鼠CD279 (PD-1) SAFIRE (Functional)

英文名称: Anti-Mouse CD279 (PD-1) SAFIRE Purified

产品编号: 31812-25-100

产品价格: null

产品产地: USA

品牌商标: peperotech(BioGems)

更新时间: null

使用范围: 功能性,流式

美国PeproTech(派普泰克)公司中国代表处
  • 联系人 :
  • 地址 :  江苏省苏州市工业园区星湖街218号A1北座4楼L03
  • 邮编 : 215123
  • 所在区域 : 江苏
  • 电话 :
  • 传真 : 0512-68325993
  • 邮箱 : peprotech.infochina@thermofisher.com

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells.
The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.