PODOPLANIN抗体Applications
In-house applications |
ELISA, IHC, WB, FC Application not tested? Please see our Guarantee. |
Published applications |
IHC |
Publications |
2 citations –view here |
Species specificity |
Human; other species not tested. |
Published Species |
Human |
Images
Prev12Next
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11629-1-AP( PDPN,D2-40,M2A Antibody) at dilution of 1:1000
- Immunohistochemical of paraffin-embedded human colon cancer using 11629-1-AP(PDPN,D2-40,M2A antibody) at dilution of 1:50 (under 10x lens)
- Immunohistochemical of paraffin-embedded human colon cancer using 11629-1-AP(PDPN,D2-40,M2A antibody) at dilution of 1:50 (under 40x lens)
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 11629-1-AP( PDPN,D2-40,M2A Antibody) at dilution of 1:1000
- 1X10^6 HUVEC cells were stained with 0.2ug PDPN,D2-40,M2A antibody (11629-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
|
Positive WB detected in |
HEK-293 cells, human placenta tissue, Transfected HEK-293 cells |
Positive IHC detected in |
Human colon cancer tissue, human lung tissue, human skeletal muscle tissue |
Positive FC detected in |
HUVEC cells |
Recommended dilution |
WB : 1:500-1:5000
IHC : 1:20-1:200 |
PODOPLANIN抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source |
Rabbit |
Purification method |
Antigen affinity purification |
Isotype |
IgG |
Storage |
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information PODOPLANIN抗体
Immunogen |
Podoplanin fusion protein ag2201 |
Full name |
Podoplanin |
Calculated molecular
weight |
17 kDa, 25 kDa |
Observed molecular
weight |
43 kDa |
GenBank accession
number |
BC022812 |
Gene ID (NCBI) |
10630 |
Gene symbol |
PDPN |
Synonyms |
AGGRUS, D2 40, D2 40,M2A, Glycoprotein 36, GP36, Gp38, GP40, HT1A 1, M2A, OTS8, PA2.26, PA2.26 antigen, PDPN, podoplanin, PSEC0025, T1 alpha, T1A, T1A 2 |
Background
M2A(D2-40) antigen is a previously identified marker for CIS and seminoma. M2A (D2-40) antigen has been identical to PDPN.(PMID: 16736189). PDPN, also named as GP36, Gp38, GP40, HT1A-1, OTS8, PA2.26, T1A and T1A-2, has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells. It may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, PDPN induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It is required for normal lung cell proliferation and alveolus formation at birth. PDPN induces platelet aggregation. It does not have any effect on folic acid or amino acid transport and does not function as a water channel or as a regulator of aquaporin-type water channels. The antibody is specific to Podoplanin. PODOPLANIN抗体
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