CEP57,睾丸特异性蛋白57抗体

产品编号HZ-13608R
英文名称CEP57
中文名称睾丸特异性蛋白57抗体
别 名Centrosomal protein 57kDa; Centrosomal protein of 57 kDa; Cep57; Cep57 protein; CEP57_HUMAN; FGF2 interacting protein; FGF2-interacting protein; KIAA0092; MVA2; PIG8; Proliferation inducing protein 8; Testis specific protein 57; Testis-specific protein 57; Translokin; TSP57.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 干细胞 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Horse,
CEP57,睾丸特异性蛋白57抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CEP57
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CEP57,睾丸特异性蛋白57抗体PubMedPubMed
产品介绍background:
CEP57 (centrosomal protein 57kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88% sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.

Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the translokin family.

Gene ID:
9702

CEP57,睾丸特异性蛋白57抗体Database links:
Entrez Gene: 9702 Human
Entrez Gene: 353245 Cow
Entrez Gene: 74360 Mouse
Entrez Gene: 315423 Rat
Omim: 607951 Human
SwissProt: Q865V0 Cow
SwissProt: Q86XR8 Human
SwissProt: Q8CEE0 Mouse
SwissProt: B4F7A7 Rat
Unigene: 101014 Human
Unigene: 157212 Mouse
Unigene: 94972 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.