RABX5,G蛋白相关RABX5抗体-抗体-抗体-生物在线
RABX5,G蛋白相关RABX5抗体

RABX5,G蛋白相关RABX5抗体

商家询价

产品名称: RABX5,G蛋白相关RABX5抗体

英文名称: Anti-RABX5 antibody

产品编号: HZ-6916R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

上海沪震实业有限公司
  • 联系人 : 鲍丽雯
  • 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
  • 邮编 : 200612
  • 所在区域 : 上海
  • 电话 : 139****0749
  • 传真 : 021-60345367
  • 邮箱 : www.shzbio.net

RABX5,G蛋白相关RABX5抗体

产品编号HZ-6916R
英文名称RABX5
中文名称G蛋白相关RABX5抗体
别 名Rabex5; RAB guanine nucleotide exchange factor (GEF) 1; Rab5 GDP/GTP exchange factor; Rab5ef; Rabaptin 5 associated exchange factor for Rab5; Rabaptin-5-associated exchange factor for Rab5; Rabex 5; Rabex-5; RABGEF 1; Rabgef1; RABX 5; RABX5; RABX5_HUMAN; RAP1; Rin 2; Rin2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
RABX5,G蛋白相关RABX5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量79kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RABX5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RABX5,G蛋白相关RABX5抗体PubMedPubMed
产品介绍background:
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]

Function:
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Subunit:
Interacts with RGS14; the interaction is GTP-dependent (By similarity). Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR

Subcellular Location:
Cytoplasm. Early endosome. Recycling endosome.

Post-translational modifications:
Monoubiquitinated.

RABX5,G蛋白相关RABX5抗体Similarity:
Contains 1 A20-type zinc finger.
Contains 1 VPS9 domain.

Database links:
Entrez Gene: 27342 Human
Entrez Gene: 56715 Mouse
Entrez Gene: 360797 Rat
Omim: 609700 Human
SwissProt: Q9UJ41 Human
SwissProt: Q9JM13 Mouse
Unigene: 530053 Human
Unigene: 288639 Mouse
Unigene: 21688 Rat

RABX5,G蛋白相关RABX5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.