KDEL,赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体

产品编号HZ-6940R
英文名称KDEL
中文名称赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体
别 名KDEL; Lys Asp Glu Leu antibody; GRP 78; GRP 94; KDEL1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Dog, Pig, Cow, Rabbit, Guinea Pig,
KDEL,赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide KDEL
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
KDEL,赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体PubMedPubMed
产品介绍background:
Endoplasmic reticulum Marker.
The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble endoplasmic reticulum (ER) resident proteins and some membrane proteins. 78 and 94 kDa glucose regulated proteins (GRP 78) and GRP 94 respectively and protein disulfide isomerase (PDI) all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subunit:
Interacts with DNAJC1 (via J domain). Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A and TRIM21. May form a complex with ERLEC1, OS9, SEL1L and SYVN1.

KDEL,赖氨酸，天冬氨酸，谷氨酸，亮氨酸相关序列抗体Subcellular Location:
Endoplasmic reticulum.

DISEASE:
Note=Autoantigen in rheumatoid arthritis.

Similarity:
Belongs to the heat shock protein 70 family.

Gene ID:
79070

Database links:
Entrez Gene: 79070 Human
Entrez Gene: 72050 Mouse
Entrez Gene: 316370 Rat
Omim: 611613 Human
SwissProt: Q6UW63 Human
SwissProt: Q9JHP7 Mouse
SwissProt: B5DFA5 Rat
Unigene: 408629 Human
Unigene: 281714 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.