Unc18-3,突触囊泡融合蛋白Unc18-3抗体

产品编号HZ-6462R
英文名称Unc18-3
中文名称突触囊泡融合蛋白Unc18-3抗体
别 名Munc18c; Munc 18 3; Munc18 3; Munc 18-3; STXB3_HUMAN; Syntaxin-binding protein 3; Platelet Sec1 protein; PSP; Protein unc-18 homolog 3; Protein unc-18 homolog C; Unc-18C; STXBP 3; STXBP3; Sxtbp3.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
Unc18-3,突触囊泡融合蛋白Unc18-3抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量68kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Unc18-3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Unc18-3,突触囊泡融合蛋白Unc18-3抗体PubMedPubMed
产品介绍background:
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Function:
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity).

Subunit:
Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4.

Subcellular Location:
Cytoplasm, cytosol. Cell membrane.

Tissue Specificity:
Megakaryocytes and platelets.

Unc18-3,突触囊泡融合蛋白Unc18-3抗体Similarity:
Belongs to the STXBP/unc-18/SEC1 family.

Gene ID:
6814

Database links:
Entrez Gene: 6814 Human
Omim: 608339 Human
SwissProt: O00186 Human
Unigene: 530436 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.