D53/TPD52L1,肿瘤蛋白D53抗体

产品编号HZ-9736R
英文名称D53/TPD52L1
中文名称肿瘤蛋白D53抗体
别 名D53; D54; hD53; hD54; Tpd52l1; TPD52L2 TPD53_HUMAN; Tumor protein D52 like 1; Tumor protein D52 like 2; Tumor protein D52-like 1; Tumor protein D53; Tumor protein D54.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 信号转导 细胞周期蛋白 激酶和磷酸酶 细胞分化 肿瘤细胞生物标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
D53/TPD52L1,肿瘤蛋白D53抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TPD52L1/D53
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
D53/TPD52L1,肿瘤蛋白D53抗体PubMedPubMed
产品介绍background:
The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.

Subunit:
Forms a homodimer or heterodimer with other members of the family.

Similarity:
Belongs to the TPD52 family.

Database links:
Entrez Gene: 7164 Human
Entrez Gene: 21987 Mouse
Omim: 604069 Human
SwissProt: Q16890 Human
SwissProt: O54818 Mouse
Unigene: 591347 Human
Unigene: 439966 Mouse

D53/TPD52L1,肿瘤蛋白D53抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.