MYLK2,肌球蛋白轻链激酶2抗体-抗体-抗体-生物在线
MYLK2,肌球蛋白轻链激酶2抗体

MYLK2,肌球蛋白轻链激酶2抗体

商家询价

产品名称: MYLK2,肌球蛋白轻链激酶2抗体

英文名称: Anti-MYLK2 antibody

产品编号: HZ-9866R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

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MYLK2,肌球蛋白轻链激酶2抗体

产品编号HZ-9866R
英文名称MYLK2
中文名称肌球蛋白轻链激酶2抗体
别 名KMLC; MLCK; MLCK2; MYLK 2; Myosin light chain kinase 2; Myosin light chain kinase 2 skeletal muscle; Myosin light chain kinase 2 skeletal/cardiac muscle; Skeletal muscle myosin light chain kinase; Skeletal myosin light chain kinase; skMLCK; MYLK2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 信号转导 激酶和磷酸酶 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,
MYLK2,肌球蛋白轻链激酶2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MYLK2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MYLK2,肌球蛋白轻链激酶2抗体PubMedPubMed
产品介绍background:
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII, CaMKIV and myosin light chain kinases (MYLK, also designated MLCK). The MYLK kinases phosphorylate myosin regulatory light chains to catalyze myosin interaction with actin filaments resulting in contractile activity. Non-muscle, smooth muscle and skeletal/cardiac muscle MYLK isoforms exist. The MYLK gene (also designated MYLK1) encodes both smooth muscle and non-muscle isoforms as well as telokin, a small C-terminal isoform expressed only in smooth muscle with the capacity to stabilize unphosphorylated myosin filaments. Multiple transcript variants are described for the MYLK gene. Smooth-muscle and non-muscle MYLK isoforms are expressed in a wide variety of adult and fetal tissues. The skeletal/cardiac muscle isoforms of MYLK are encoded by a separate gene, MYLK2 (also designated skMLCK). MYLK appears to be a target for PAKs (p21-activated kinases). PAK1 interaction with MYLK results in a decrease in MYLK activity and myosin light chain phosphorylation.

Function:
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.

Subunit:
May interact with centrin.

Subcellular Location:
Cytoplasmic. Co-localizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.

Tissue Specificity:
heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.

DISEASE:
Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

MYLK2,肌球蛋白轻链激酶2抗体Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

Database links:
Entrez Gene: 85366 Human
Omim: 606566 Human
SwissProt: Q9H1R3 Human
Unigene: 86092 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.