PAPP A2,妊娠相关血浆蛋白A2抗体

产品编号HZ-9916R
英文名称PAPP A2
中文名称妊娠相关血浆蛋白A2抗体
别 名PAPPA 2; PAPP E; PAPP-A2; PAPP-E; PAPP2_HUMAN; PAPPA 2; PAPPA2; Pappalysin 2; Pappalysin-2; PLAC3; Pregnancy associated plasma protein A2; Pregnancy associated plasma protein E1; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
PAPP A2,妊娠相关血浆蛋白A2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量173kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PAPP A2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PAPP A2,妊娠相关血浆蛋白A2抗体PubMedPubMed
产品介绍background:
Pregnancy-associated plasma protein-A (Pappalysin-1 or PAPP-A), also known as Insulin-like growth factor-dependent IGF-binding protein 4 (IGFBP4) protease, is a member of the peptidase M43B family of proteins. PAPP-A, a metalloproteinase, cleaves Insulin-like growth factor binding proteins IGFBP4 and IGFBP5, releasing bound IGF. PAPP-A is primarily expressed in septa and anchoring villi in placenta and is also expressed in pregnancy serum. Levels of PAPP-A increase throughout pregnancy. Lower levels of expression can be detected in kidney, prostate, breast, ovary and endometrial tissues. PAPP-A is a secreted protein that can form homodimers; in pregnancy serum PAPP-A may also form a heterotetramer with PRG-2.

Function:
Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Subunit:
Monomer.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.

Similarity:
Belongs to the peptidase M43B family.
Contains 5 Sushi (CCP/SCR) domains.

Database links:
Entrez Gene: 60676 Human
Entrez Gene: 23850 Mouse
Entrez Gene: 364027 Rat
SwissProt: Q9BXP8 Human
Unigene: 187284 Human
Unigene: 458621 Mouse

PAPP A2,妊娠相关血浆蛋白A2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.